Hamadan University of Medical Sciences Avicenna journal of Care and Health in Operating Room 2981-0639 1 3 2023 11 21 Evaluation of Blood Transfusion-Related Reactions of Blood Recipients in Hamadan Besat Hospital Patients during 2020- 2022 94 98 10.34172/ajchor.36 EN Mohammad Rezaei https://orcid.org/0009-0005-0435-9170 Fatemeh Amiri https://orcid.org/0000-0002-9976-4734 Mahta Razaghi Farshid Mohammadi Journal Article 10.34172/ajchor.36 2023 10 31 2023 11 09 Background: Blood transfusion has some complications known as transfusion-related reactions. Accurate identification and recording of these reactions is more important for their management and prevention. This study aimed to evaluate blood transfusion-related reactions in blood recipients in patients in Hamadan Besat hospital during 2020-2022. Methods: In this cross-sectional study, the data of 400 patients who had complications after receiving blood and blood components were collected in terms of hemolytic and non-hemolytic blood transfusion reactions. Data were collected from patients’ medical records and standard blood transfusion checklists and analyzed by SPSS version 26 software using the chi-square test and Fisher’s exact test. Results: Red blood cell (RBC), 70.25%, random donor platelet (RDP), 10.3%, and fresh frozen plasma (FFP), 9.5%, were the most transfused blood components. Blood transfusion reactions were allergic reactions (53.5%), febrile non-hemolytic transfusion reaction (FNHTR) (24%), dyspnea (10.25%), hemolytic reactions (HR) (4.5%), hypotension (4.25%), transfusion-associated cardiovascular overload (TACO) (1.75%), and other reactions (2.75%). A significant relationship was also observed between receiving components containing RBC, including whole blood (WB0), RBC concentrate, and leukoreduced RBC, and the incidence of FNHTR (P=0.001). Conclusion: Based on the findings of the present study, allergic reaction and FNHTR were the most common complications after blood transfusions. Blood transfusion-related reactions could be predicted, managed, and possibly prevented by considering the relationship between the type of reaction and the type of transfused blood components.