Hamadan University of Medical Sciences Avicenna journal of Care and Health in Operating Room 2981-0639 2 2 2024 07 31 Comparing Plasma Fibrinogen,Homocysteine, Cardiac Troponin I, and C-Reactive Protein Levels Among Smokers and Non-smokers inHamadan Hospitals: A Case-Control Study 71 74 10.34172/ajchor.61 EN Mohammad Reza Safari https://orcid.org/0000-0001-6768-6156 Mohsen Rezaee Saeid Amiri Journal Article 10.34172/ajchor.61 2024 04 24 2024 06 09 Background: Cigarette smoking is one of the main risk factors for cardiovascular damage. Current studies have reported an association between some markers such as homocysteine, plasma fibrinogen, cardiac troponin I (cTnI), and C-reactive protein (CRP) and cardiovascular damages. This study aimed to investigate the relationship between these laboratory markers and smoking intensity. Methods: In this case-control study, 200 male employees from the operating room, laboratory, and administrative departments of Hamadan hospitals were categorized into four groups of 50 based on their smoking status: active smokers, smokers, infrequent smokers, and non-smokers. After sampling, blood levels of the specified biomarkers were evaluated. Then, regression analysis was performed to explore the relationship between these markers and cigarette smoking, regression analysis was performed. Results: The results indicated significant differences in the studied biomarkers between smokers and non-smokers (P<0.001), suggesting the effect of cigarette smoking on cardiovascular damage, inflammation, and coagulation states in individuals. Conclusion: Cigarette smoking affects markers of heart muscle damage, inflammatory and coagulation factors, and cardiovascular risk factors.