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Submitted: 23 Oct 2023
Revision: 05 Nov 2023
Accepted: 08 Nov 2023
ePublished: 21 Nov 2023
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Avicenna J Care Health Oper Room. 2023;1(3): 90-93.
doi: 10.34172/ajchor.34
  Abstract View: 106
  PDF Download: 85
  Full Text View: 22

Original Article

Determination of Plasma Malondialdehyde Values as a Laboratory Index of Lipid Peroxidation Reaction in Multiple Sclerosis Patients and Its Comparison With Normal People

Zahra Goli 1 ORCID logo, Soudabeh Mashayekhi 1, Mohammad Taheri 2, Mehrdokht Mazdeh 3, Mohammad Reza Safari 2* ORCID logo

1 Clinical Chemistry Department, Hamadan University of Medical Sciences, Hamadan, Iran
2 Medical Laboratory Department, Hamadan University of Medical Sciences, Hamadan, Iran
3 Neurology Department, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author: Mohammad Reza Safari, Email: safarimr2000@yahoo.com

Abstract

Background: Lipid peroxidation reaction and plasma malondialdehyde (MDA) production are important prognoses in the formation and development of neurodegenerative diseases. The link between lipid peroxidation reaction and plasma MDA in multiple sclerosis (MS) patients is poorly understood. In this study, the plasma MDA values of people with MS and normal people were measured.

Methods: In this study, 70 patients with MS and 70 thermally healthy individuals were selected. Their blood samples were poured into the buffer, and the plasma was separated. Then, plasma MDA values were measured through the thiobarbituric acid (TBA) method.

Results: The results showed that the values of plasma MDA in two groups of patients with MS and healthy people are 1.49±0.46 and 0.58±0.15 μmol/L, respectively.

Conclusion: The findings of this research revealed that the levels of plasma MDA in MS patients are higher than those in healthy people. Therefore, these patients exhibited elevated oxidative stress.


Please cite this article as follows: Goli Z, Mashayekhi S, Taheri M, Mazdeh M, Safari MR. Determination of plasma malondialdehyde values as a laboratory index of lipid peroxidation reaction in multiple sclerosis patients and its comparison with normal people. Avicenna J Care Health Oper Room. 2023; 1(3):90-93. doi:10.34172/ajchor.34
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